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KMID : 0376419810050020217
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Chonbuk University Medical Journal
1981 Volume.5 No. 2 p.217 ~ p.222
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Some Conditions Changing the Pressor Responses of Arginine Vasoressin in the Rat.
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Abstract
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Vascular reactivity and so pressure response can be changed in some different conditions to the same agonist. In this experiment, pressor responses in the several different conditions of the arginine vasopressin was investgated.
1. Arginine vasopressin increased the pressor response in the doses of 1, 3, 10, 30, 100, 300mu/kg, iv., and showed dose response curve.
2. Acute infusion of hypotonic solution under alcohol anesthesia showed accentuated resronses to the same ranges of ADH over control.
3. Unilateral nephietomy or chronic saline ingestion elicite accentuated responses.
4. Pressor responses to arginine vasopressin were not changed in the adrenalectomized, o.9% NaCl ingested, hydrocortisone treated rat compared to its responsible control rats.
These data suggest the pressor responses to arginine vasopressin could be changed in certain conditions.
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